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KMID : 1011320130060010017
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Journal of Pharmacoepidemiology and Risk Management
2013 Volume.6 No. 1 p.17 ~ p.32
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Drug-induced Pancreatitis
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Lee Jun-Kyu
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Abstract
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Drug is known to be the third most common etiology of acute pancreatitis and 525 different drugs that can induce acute pancreatitis as a side effect are listed in a WHO database. However, the diagnosis of drug-induced pancreatitis is often difficult to be made since all other causes of pancreatitis such as alcohol and gallstones should be excluded. Drugs with positive rechallenge and/or consistent latency are considered to have the strongest evidence for cause and effect relationship. Among drugs with strong evidences, angiotensin converting enzyme inhibitors, azathioprine/6-mercaptopurine, benzafibrate, codeine, 5-aminosalysilic acids, isoniazid, stibogluconate/meglumine, statin, tetracycline, valproic acid are of special concern because chance is relatively high and/or development of severe disease is possible. The pathophysiologic mechanisms are vastly unknown and need to be elucidated. There is no difference in the principles of treatment between drug-induced pancreatitis and pancreatitis of any other causes but benefits and risks should be weighed before deciding to continue or rechallenge offending drugs.
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KEYWORD
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Acute pancreatitis, Drug-induced pancreatitis, Drug side effect
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FullTexts / Linksout information
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